Challenges in severe asthma
Significant challenges exist in severe asthma, such as persistent exacerbations, hospitalizations, and symptoms contributing to poor quality of life.2
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Access videoSignificant challenges exist in severe asthma, such as persistent exacerbations, hospitalizations, and symptoms contributing to poor quality of life.2
Epithelial dysregulation is implicated in both upper and lower airway diseases1,2
Airway hyperresponsiveness results from an intricate interplay of airway inflammation, airway remodeling, and structural changes.1–3
Epithelial cytokines (eg, TSLP) are released in response to triggers, initiating a cascade of immune responses that drive clinical features of asthma.1–4
Overlapping and changing inflammatory pathways in response to an exacerbation, trigger, or treatment change highlight the complexity of severe asthma.1–4
The airway epithelium is the first point of contact for environmental triggers and initiates inflammation and structural changes that contribute to asthma.1–3
Professor Louis-Philippe Boulet, MD, FRCPC
Professor of Medicine, Department of Medicine, Laval University
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Download this slide deck describing the roles of airway inflammation, airway remodeling, and structural changes in airway hyperresponsiveness.
Download this slide deck outlining the different testing methods for airway hyperresponsiveness.
Download this one-page infographic summarizing the important roles TSLP and mast cells play in allergic T2 and T2-independent pathways.
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Dr Jonathan Corren describes the inflammatory pathways that underpin the complexity of inflammation in severe asthma.
Dr Michael E Wechsler describes the heterogeneity of severe asthma and the burden of uncontrolled disease on the lives of patients with severe asthma.
Watch this video to learn more about the pathological changes that occur in the airways of people with asthma and how this manifests as clinical symptoms.
Watch this video to learn more about how TSLP interacts with mast cells in asthma, contributing to airway hyperresponsiveness.
Watch this video to learn more about the role of epithelial cytokines in asthma and their role in driving disease pathogenesis.